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β-Lactamases: A Focus on Current Challenges
β-Lactamases, the enzymes that hydrolyze β-lactam antibiotics, remain the greatest threat to the usage of these agents. In this review, the mechanism of hydrolysis is discussed for both those enzymes that use serine at the active site and those that require divalent zinc ions for hydrolysis. The β-l...
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| Publicado no: | Cold Spring Harb Perspect Med |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5204326/ https://ncbi.nlm.nih.gov/pubmed/27742735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a025239 |
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