Hepatocytes Are the Principal Source of Circulating RBP4 in Mice

RBP4 is produced mainly by hepatocytes. In type 2 diabetes and obesity, circulating RBP4 is increased and may act systemically to cause insulin resistance and glucose intolerance. Observations that adipocyte RBP4 mRNA increases in parallel with circulating RBP4 in these conditions, whereas liver RBP...

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Bibliographic Details
Published in:Diabetes
Main Authors: Thompson, Spencer J., Sargsyan, Ashot, Lee, Seung-Ah, Yuen, Jason J., Cai, Jinjin, Smalling, Rana, Ghyselinck, Norbert, Mark, Manuel, Blaner, William S., Graham, Timothy E.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2017
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204311/
https://ncbi.nlm.nih.gov/pubmed/27797907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0286
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