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Hepatocytes Are the Principal Source of Circulating RBP4 in Mice

RBP4 is produced mainly by hepatocytes. In type 2 diabetes and obesity, circulating RBP4 is increased and may act systemically to cause insulin resistance and glucose intolerance. Observations that adipocyte RBP4 mRNA increases in parallel with circulating RBP4 in these conditions, whereas liver RBP...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Thompson, Spencer J., Sargsyan, Ashot, Lee, Seung-Ah, Yuen, Jason J., Cai, Jinjin, Smalling, Rana, Ghyselinck, Norbert, Mark, Manuel, Blaner, William S., Graham, Timothy E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204311/
https://ncbi.nlm.nih.gov/pubmed/27797907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0286
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