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Partial Purification of a Megadalton DNA Replication Complex by Free Flow Electrophoresis

We describe a gentle and rapid method to purify the intact multiprotein DNA replication complex using free flow electrophoresis (FFE). In particular, we applied FFE to purify the human cell DNA synthesome, which is a multiprotein complex that is fully competent to carry-out all phases of the DNA rep...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Li, Caroline M., Miao, Yunan, Lingeman, Robert G., Hickey, Robert J., Malkas, Linda H.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201288/
https://ncbi.nlm.nih.gov/pubmed/28036377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169259
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