Structural and Catalytic Properties of S1 Nuclease from Aspergillus oryzae Responsible for Substrate Recognition, Cleavage, Non–Specificity, and Inhibition

The single–strand–specific S1 nuclease from Aspergillus oryzae is an archetypal enzyme of the S1–P1 family of nucleases with a widespread use for biochemical analyses of nucleic acids. We present the first X–ray structure of this nuclease along with a thorough analysis of the reaction and inhibition...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Kovaľ, Tomáš, Østergaard, Lars H., Lehmbeck, Jan, Nørgaard, Allan, Lipovová, Petra, Dušková, Jarmila, Skálová, Tereza, Trundová, Mária, Kolenko, Petr, Fejfarová, Karla, Stránský, Jan, Švecová, Leona, Hašek, Jindřich, Dohnálek, Jan
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201275/
https://ncbi.nlm.nih.gov/pubmed/28036383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168832
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