Structural and Catalytic Properties of S1 Nuclease from Aspergillus oryzae Responsible for Substrate Recognition, Cleavage, Non–Specificity, and Inhibition

The single–strand–specific S1 nuclease from Aspergillus oryzae is an archetypal enzyme of the S1–P1 family of nucleases with a widespread use for biochemical analyses of nucleic acids. We present the first X–ray structure of this nuclease along with a thorough analysis of the reaction and inhibition...

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Veröffentlicht in:PLoS One
Hauptverfasser: Kovaľ, Tomáš, Østergaard, Lars H., Lehmbeck, Jan, Nørgaard, Allan, Lipovová, Petra, Dušková, Jarmila, Skálová, Tereza, Trundová, Mária, Kolenko, Petr, Fejfarová, Karla, Stránský, Jan, Švecová, Leona, Hašek, Jindřich, Dohnálek, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201275/
https://ncbi.nlm.nih.gov/pubmed/28036383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168832
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