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Polymyxins facilitate entry into mammalian cells
Polymyxin B is an antibiotic used against multi-resistant Gram negative infections, despite observed nephrotoxicity. Here we report the synthesis of functionalized derivatives of polymyxin B and its per-guanidinylated derivative in order to further explore the structural requirements necessary to fa...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5201209/ https://ncbi.nlm.nih.gov/pubmed/28044098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00488a |
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