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A WD-Repeat Protein Stabilizes ORC Binding to Chromatin

Origin recognition complex (ORC) plays critical roles in the initiation of DNA replication and cell-cycle progression. In metazoans, ORC associates with origin DNA during G1 and with heterochromatin in postreplicated cells. However, what regulates the binding of ORC to chromatin is not understood. W...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Shen, Zhen, Sathyan, Kizhakke M., Geng, Yijie, Zheng, Ruiping, Chakraborty, Arindam, Freeman, Brian, Wang, Fei, Prasanth, Kannanganattu V., Prasanth, Supriya G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201136/
https://ncbi.nlm.nih.gov/pubmed/20932478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.09.021
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