SIRT1 inhibits EV71 genome replication and RNA translation by interfering with the viral polymerase and 5′UTR RNA

Enterovirus 71 (EV71) possesses a single-stranded positive RNA genome that contains a single open reading frame (ORF) flanked by a 5′ untranslated region (5′UTR) and a polyadenylated 3′UTR. Here, we demonstrated that EV71 activates the production of silent mating type information regulation 2 homolo...

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Veröffentlicht in:J Cell Sci
Hauptverfasser: Han, Yang, Wang, Lvyin, Cui, Jin, Song, Yu, Luo, Zhen, Chen, Junbo, Xiong, Ying, Zhang, Qi, Liu, Fang, Ho, Wenzhe, Liu, Yingle, Wu, Kailang, Wu, Jianguo
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201017/
https://ncbi.nlm.nih.gov/pubmed/27875274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.193698
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