Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus

The class III phosphoinositide 3-kinase (PI3K) Vps34 (also known as PIK3C3 in mammals) produces phosphatidylinositol 3-phosphate [PI(3)P] on both early and late endosome membranes to control membrane dynamics. We used Vps34-deficient cells to delineate whether Vps34 has additional roles in endocytic...

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Udgivet i:J Cell Sci
Main Authors: Jaber, Nadia, Mohd-Naim, Noor, Wang, Ziqing, DeLeon, Jennifer L., Kim, Seong, Zhong, Hua, Sheshadri, Namratha, Dou, Zhixun, Edinger, Aimee L., Du, Guangwei, Braga, Vania M. M., Zong, Wei-Xing
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201010/
https://ncbi.nlm.nih.gov/pubmed/27793976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.192260
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