Activity of fluorine–containing analogues of WC-9 and structurally related analogues against two intracellular parasites: Trypanosoma cruzi and Toxoplasma gondii

Two obligate intracellular parasites, Trypanosoma cruzi, agent of Chagas disease, and Toxoplasma gondii, agent of toxoplasmosis, upregulate the mevalonate pathway of their host cells upon infection, suggesting that this host pathway could be a potential drug target. In this work we designed, synthes...

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Pubblicato in:ChemMedChem
Autori principali: Chao, María N., Li, Catherine, Storey, Melissa, Falcone, Bruno N., Szajnman, Sergio H., Bonesi, Sergio M., Docampo, Roberto, Moreno, Silvia N. J., Rodriguez, Juan B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5200956/
https://ncbi.nlm.nih.gov/pubmed/27886451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600505
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