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Molecular insights into Adgra2/Gpr124 and Reck intracellular trafficking

Adgra2, formerly known as Gpr124, is a key regulator of cerebrovascular development in vertebrates. Together with the GPI-anchored glycoprotein Reck, this adhesion GPCR (aGPCR) stimulates Wnt7-dependent Wnt/β-catenin signaling to promote brain vascular invasion in an endothelial cell-autonomous mann...

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Publicat a:Biol Open
Autors principals: Bostaille, Naguissa, Gauquier, Anne, Twyffels, Laure, Vanhollebeke, Benoit
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5200908/
https://ncbi.nlm.nih.gov/pubmed/27979830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.021287
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