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Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice

KEY POINTS: Spinocerebellar ataxia type 1 (SCA1) is a progressive neurodegenerative disease caused by a gene defect, leading to movement disorder such as cerebellar ataxia. It remains largely unknown which functional defect contributes to the cerebellar ataxic phenotype in SCA1. In this study, we re...

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Bibliographische Detailangaben
Veröffentlicht in:J Physiol
Hauptverfasser: Shuvaev, Anton N., Hosoi, Nobutake, Sato, Yamato, Yanagihara, Dai, Hirai, Hirokazu
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199750/
https://ncbi.nlm.nih.gov/pubmed/27440721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272950
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