Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury

Fibrotic disease is associated with matrix deposition that results in the loss of organ function. Pericytes, the precursors of myofibroblasts, are a source of pathological matrix collagens and may be promising targets for treating fibrogenesis. Here, we have shown that pericytes activate a TLR2/4- a...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Leaf, Irina A., Nakagawa, Shunsaku, Johnson, Bryce G., Cha, Jin Joo, Mittelsteadt, Kristen, Guckian, Kevin M., Gomez, Ivan G., Altemeier, William A., Duffield, Jeremy S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199713/
https://ncbi.nlm.nih.gov/pubmed/27869651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87532
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