Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury

Fibrotic disease is associated with matrix deposition that results in the loss of organ function. Pericytes, the precursors of myofibroblasts, are a source of pathological matrix collagens and may be promising targets for treating fibrogenesis. Here, we have shown that pericytes activate a TLR2/4- a...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Leaf, Irina A., Nakagawa, Shunsaku, Johnson, Bryce G., Cha, Jin Joo, Mittelsteadt, Kristen, Guckian, Kevin M., Gomez, Ivan G., Altemeier, William A., Duffield, Jeremy S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199713/
https://ncbi.nlm.nih.gov/pubmed/27869651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87532
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