Pharmacodynamic and Pharmacokinetic Evaluation of Two Dosing Schedules of Indotecan (LMP400), a Novel Indenoisoquinoline, in Patients with Advanced Solid Tumors

BACKGROUND: Indenoisoquinolines are non-camptothecin topoisomerase 1 (Top1) inhibitors with activity against camptothecin-resistant cell lines. Two dosing schedules of the novel indenoisoquinoline, indotecan (LMP400), were evaluated in patients with advanced solid tumors. METHODS: The maximum tolera...

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Publicado no:Cancer Chemother Pharmacol
Main Authors: Kummar, Shivaani, Chen, Alice, Gutierrez, Martin, Pfister, Thomas D., Wang, Lihua, Redon, Christophe, Bonner, William M., Yutzy, William, Zhang, Yiping, Allen, Deborah, Eiseman, Julie L., Holleran, Julianne L., Beumer, Jan H., Rubinstein, Larry, Collins, Jerry, Tomaszewski, Joseph, Parchment, Ralph, Pommier, Yves, Doroshow, James H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199138/
https://ncbi.nlm.nih.gov/pubmed/27169793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-2998-6
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