Design and synthesis of fluorescent acyclic nucleoside phosphonates as potent inhibitors of bacterial adenylate cyclases

Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema factor (EF) are key virulence factors with adenylate cyclase (AC) activity that substantially contribute to the pathogenesis of whooping cough and anthrax, respectively. There is an urgent need to develop potent and sele...

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Publicat a:ChemMedChem
Autors principals: Břehová, Petra, Šmídková, Markéta, Skácel, Jan, Dračínský, Martin, Mertlíková-Kaiserová, Helena, Velasquez, Monica P. Soto, Watts, Val J., Janeba, Zlatko
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198786/
https://ncbi.nlm.nih.gov/pubmed/27775243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600439
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