Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis

A series of 13 acyclic nucleoside phosphonates (ANPs) as bisamidate prodrugs was prepared. Five compounds were found to be non-cytotoxic and selective inhibitors of Bordetella pertussis adenylate cyclase toxin (ACT) in J774A.1 macrophage cell-based assays. The 8-aza-7-deazapurine derivative of adefo...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Česnek, Michal, Skácel, Jan, Jansa, Petr, Dračínský, Martin, Šmídková, Markéta, Mertlíková-Kaiserová, Helena, Soto-Velasquez, Monica P., Watts, Val J., Janeba, Zlatko
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415679/
https://ncbi.nlm.nih.gov/pubmed/29968968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800332
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