Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis

A series of 13 acyclic nucleoside phosphonates (ANPs) as bisamidate prodrugs was prepared. Five compounds were found to be non-cytotoxic and selective inhibitors of Bordetella pertussis adenylate cyclase toxin (ACT) in J774A.1 macrophage cell-based assays. The 8-aza-7-deazapurine derivative of adefo...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:ChemMedChem
Main Authors: Česnek, Michal, Skácel, Jan, Jansa, Petr, Dračínský, Martin, Šmídková, Markéta, Mertlíková-Kaiserová, Helena, Soto-Velasquez, Monica P., Watts, Val J., Janeba, Zlatko
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415679/
https://ncbi.nlm.nih.gov/pubmed/29968968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800332
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares