Design and synthesis of fluorescent acyclic nucleoside phosphonates as potent inhibitors of bacterial adenylate cyclases

Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema factor (EF) are key virulence factors with adenylate cyclase (AC) activity that substantially contribute to the pathogenesis of whooping cough and anthrax, respectively. There is an urgent need to develop potent and sele...

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Publicado no:ChemMedChem
Main Authors: Břehová, Petra, Šmídková, Markéta, Skácel, Jan, Dračínský, Martin, Mertlíková-Kaiserová, Helena, Velasquez, Monica P. Soto, Watts, Val J., Janeba, Zlatko
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198786/
https://ncbi.nlm.nih.gov/pubmed/27775243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600439
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