Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1)()

Coactivator-associated arginine methyltransferase 1 (CARM1) is a type I protein arginine methyltransferase (PRMT) that catalyzes the conversion of arginine into monomethylarginine (MMA) and further into asymmetric dimethylarginine (ADMA). CARM1 methylates histone 3 arginines 17 and 26, as well as nu...

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Publicado no:Medchemcomm
Main Authors: Kaniskan, H. Ü., Eram, M. S., Liu, J., Smil, D., Martini, M. L., Shen, Y., Santhakumar, V., Brown, P. J., Arrowsmith, C., Vedadi, M., Jin, J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198778/
https://ncbi.nlm.nih.gov/pubmed/28042453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6MD00342G
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