Double Knockout of the Na(+)-Driven Cl(−)/HCO(3)(−) Exchanger and Na(+)/Cl(−) Cotransporter Induces Hypokalemia and Volume Depletion

We recently described a novel thiazide–sensitive electroneutral NaCl transport mechanism resulting from the parallel operation of the Cl(−)/HCO(3)(−) exchanger pendrin and the Na(+)–driven Cl(−)/2HCO(3)(−) exchanger (NDCBE) in β-intercalated cells of the collecting duct. Although a role for pendrin...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Sinning, Anne, Radionov, Nikita, Trepiccione, Francesco, López-Cayuqueo, Karen I., Jayat, Maximilien, Baron, Stéphanie, Cornière, Nicolas, Alexander, R. Todd, Hadchouel, Juliette, Eladari, Dominique, Hübner, Christian A., Chambrey, Régine
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2017
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198265/
https://ncbi.nlm.nih.gov/pubmed/27151921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070734
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