Normal serum immunoglobulins participate in the selection of peripheral B-cell repertoires.
In B-cell development, expression of immunoglobulin heavy-chain variable-region (VH) gene repertoires is determined by genetic mechanisms that favor rearrangement of the most D-proximal genes, resulting in overutilization of the VH7183 gene family early in ontogeny and in differentiating B cells of...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51933/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1829525/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.13.5640 |
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