Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD−iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3

Systemic lupus erythematosus (SLE) is an autoimmune disease that reflects a failure to block the production of self-reactive antibodies, especially those that bind double-stranded DNA (dsDNA). Backcrossing the lupus-prone NZM2410 genome onto C57BL/6 led to the identification of three genomic interva...

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Autori principali:	Mohamed Khass, Robert L. Schelonka, Cun Ren Liu, Ada Elgavish, Laurence Morel, Peter D. Burrows, Harry W. Schroeder
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2017-01-01
Serie:	Autoimmunity
Soggetti:	systemic lupus erythematosus sle b-cell repertoire third complementary determining region heavy chain cdr-h3 and diversity gene segments dh
Accesso online:	http://dx.doi.org/10.1080/08916934.2016.1272597
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