An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methy...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Pharmacol Exp Ther
المؤلفون الرئيسيون: Svensson, Kjell A., Heinz, Beverly A., Schaus, John M., Beck, James P., Hao, Junliang, Krushinski, Joseph H., Reinhard, Matthew R., Cohen, Michael P., Hellman, Sarah L., Getman, Brian G., Wang, Xushan, Menezes, Michelle M., Maren, Deanna L., Falcone, Julie F., Anderson, Wesley H., Wright, Rebecca A., Morin, S. Michelle, Knopp, Kelly L., Adams, Benjamin L., Rogovoy, Borys, Okun, Ilya, Suter, Todd M., Statnick, Michael A., Gehlert, Donald R., Nelson, David L., Lucaites, Virginia L., Emkey, Renee, DeLapp, Neil W., Wiernicki, Todd R., Cramer, Jeffrey W., Yang, Charles R., Bruns, Robert F.
التنسيق: Artigo
اللغة:Inglês
منشور في: The American Society for Pharmacology and Experimental Therapeutics 2017
الموضوعات:
Neuropharmacology
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193077/
https://ncbi.nlm.nih.gov/pubmed/27811173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.236372
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