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Tachyphylaxis to the anti-tetanus activity of some phenothiazine compounds

Although chlorpromazine and acepromazine were the most potent suppressants of local tetanus induced in rabbits by intramuscular injection of the toxin of Cl. tetani, repeated injections lost their effect (tachyphylaxis) and sometimes even increased muscle activity, as did single large injections of...

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Detalhes bibliográficos
Main Authors: Laurence, D. R., Webster, R. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 1961
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482022/
https://ncbi.nlm.nih.gov/pubmed/13759492
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