An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methy...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Pharmacol Exp Ther
Autors principals: Svensson, Kjell A., Heinz, Beverly A., Schaus, John M., Beck, James P., Hao, Junliang, Krushinski, Joseph H., Reinhard, Matthew R., Cohen, Michael P., Hellman, Sarah L., Getman, Brian G., Wang, Xushan, Menezes, Michelle M., Maren, Deanna L., Falcone, Julie F., Anderson, Wesley H., Wright, Rebecca A., Morin, S. Michelle, Knopp, Kelly L., Adams, Benjamin L., Rogovoy, Borys, Okun, Ilya, Suter, Todd M., Statnick, Michael A., Gehlert, Donald R., Nelson, David L., Lucaites, Virginia L., Emkey, Renee, DeLapp, Neil W., Wiernicki, Todd R., Cramer, Jeffrey W., Yang, Charles R., Bruns, Robert F.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2017
Matèries:
Neuropharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193077/
https://ncbi.nlm.nih.gov/pubmed/27811173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.236372
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars