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Characterization of the Folding of a 5(2)-Knotted Protein Using Engineered Single-Tryptophan Variants

An increasing number of proteins that contain topological knots have been identified over the past two decades; however, their folding mechanisms are still not well understood. UCH-L1 has a 5(2)-knotted topology. Here, we constructed a series of variants that contain a single tryptophan at different...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Zhang, Hongyu, Jackson, Sophie E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192476/
https://ncbi.nlm.nih.gov/pubmed/28002735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.10.029
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