Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of (14)C-Omadacycline in Rats

The absorption, distribution, metabolism, and excretion (ADME) of omadacycline, a first-in-class aminomethylcycline antibiotic with a broad spectrum of activity against Gram-positive, Gram-negative, anaerobic, and atypical bacteria, were evaluated in rats. Tissue distribution was investigated by qua...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Lin, Wen, Flarakos, Jimmy, Du, Yancy, Hu, Wenyu, He, Handan, Mangold, James, Tanaka, S. Ken, Villano, Stephen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192155/
https://ncbi.nlm.nih.gov/pubmed/27821446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01784-16
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