Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition

Efavirenz pharmacokinetics is characterized by large between-subject variability, which determines both therapeutic response and adverse effects. Some of the variability in efavirenz pharmacokinetics has been attributed to genetic variability in cytochrome P450 genes that alter efavirenz metabolism,...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Robarge, Jason D., Metzger, Ingrid F., Lu, Jessica, Thong, Nancy, Skaar, Todd C., Desta, Zeruesenay, Bies, Robert R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192152/
https://ncbi.nlm.nih.gov/pubmed/27799204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01813-16
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