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An Enhanced Emtricitabine-Loaded Long-Acting Nanoformulation for Prevention or Treatment of HIV Infection

Among various FDA-approved combination antiretroviral drugs (cARVs), emtricitabine (FTC) has been a very effective nucleoside reverse transcriptase inhibitor. Thus far, FTC is the only deoxycytidine nucleoside analog. However, a major drawback of FTC is its large volume distribution (averaging 1.4 l...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Mandal, Subhra, Belshan, Michael, Holec, Ashley, Zhou, You, Destache, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192106/
https://ncbi.nlm.nih.gov/pubmed/27821449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01475-16
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