MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling

Constitutive STAT3 activation by tyrosine phosphorylation of mutated or amplified tyrosine kinases (pYSTAT3) is critical for cancer initiation, progression, invasion, and motility of carcinoma cells. We showed that AF1q is associated with STAT3 signaling in breast cancer cells. In xenograft models,...

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Pubblicato in:Oncotarget
Autori principali: Park, Jino, Kim, Soojin, Joh, Joongho, Remick, Scot C., Miller, Donald M., Yan, Jun, Kanaan, Zeyad, Chao, Ju-Hsien, Krem, Maxwell M., Basu, Soumit K., Hagiwara, Shotaro, Kenner, Lukas, Moriggl, Richard, Bunting, Kevin D., Tse, William
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190071/
https://ncbi.nlm.nih.gov/pubmed/27259262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9759
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