Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells

The secretion of soluble pro-angiogenic factors by tumor cells and stromal cells in the perivascular niche promotes the aggressive angiogenesis that is typical of glioblastoma (GBM). Here, we show that angiogenesis also can be promoted by a direct interaction between brain tumor cells, including tum...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Burgett, Monica E., Lathia, Justin D., Roth, Patrick, Nowacki, Amy S., Galileo, Deni S., Pugacheva, Elena, Huang, Ping, Vasanji, Amit, Li, Meizhang, Byzova, Tatiana, Mikkelsen, Tom, Bao, Shideng, Rich, Jeremy N., Weller, Michael, Gladson, Candece L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190064/
https://ncbi.nlm.nih.gov/pubmed/27270311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9700
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