Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy

Vascular endothelial growth factor A (VEGF-A) inhibition with pazopanib is an approved therapy for sarcomas, but likely results in compensatory pathways such as upregulation of hypoxia inducible factor 1α (HIF-1α). In addition, cancer stem-like cells can preferentially reside in hypoxic regions of t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yoon, Changhwan, Chang, Kevin K., Lee, Jun Ho, Tap, William D., Hart, Charles P., Simon, M. Celeste, Yoon, Sam S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5189991/
https://ncbi.nlm.nih.gov/pubmed/27374091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10212
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