Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting µ Opioid Analgesic with Reduced Abuse Liability

Opioids are widely used to treat millions suffering from pain, but their analgesic utility is limited due to associated side effects. Herein we report the development and evaluation of a chemical probe exhibiting analgesia and reduced opioid-induced side effects. This compound, kurkinorin (5), is a...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Crowley, Rachel Saylor, Riley, Andrew P., Sherwood, Alexander M., Groer, Chad E., Shivaperumal, Nirajmohan, Biscaia, Miguel, Paton, Kelly, Schneider, Sebastian, Provasi, Davide, Kivell, Bronwyn M., Filizola, Marta, Prisinzano, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5189922/
https://ncbi.nlm.nih.gov/pubmed/27958743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01235
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