Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity

Autologous T cells genetically modified to express a chimeric antibody receptor (CAR) against carboxy-anhydrase-IX (CAIX) were administered to 12 patients with CAIX-expressing metastatic renal cell carcinoma (RCC). Patients were treated in three cohorts with a maximum of 10 infusions of a total of 0...

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Veröffentlicht in:Mol Ther
Hauptverfasser: Lamers, Cor HJ, Sleijfer, Stefan, van Steenbergen, Sabine, van Elzakker, Pascal, van Krimpen, Brigitte, Groot, Corrien, Vulto, Arnold, den Bakker, Michael, Oosterwijk, Egbert, Debets, Reno, Gratama, Jan W
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5189272/
https://ncbi.nlm.nih.gov/pubmed/23423337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.17
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