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Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins

The P3k oncoprotein [homolog of the catalytic subunit p110α of class 1A phosphoinositide 3-kinase (PI3K)] and its downstream effector Akt induce oncogenic transformation in cultures of chicken embryo fibroblasts (CEF). The winged helix transcription factor FoxO1 is a growth-attenuating and proapopto...

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Autors principals: Aoki, Masahiro, Jiang, Hao, Vogt, Peter K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC518802/
https://ncbi.nlm.nih.gov/pubmed/15342912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405454101
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