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Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2, 6-dioxopiperidines and 3-substituted 2, 6-dioxopiperidines for TNF-α inhibitory activity
Eight novel 2-(2, 6-dioxopiperidin-3-yl)phthalimidine EM-12 dithiocarbamates 9 and 10, N-substituted 3-(phthalimidin-2-yl)-2, 6-dioxopiperidines 11–14 and 3-substituted 2, 6-dioxopiperidines 16 and 18 were synthesized as tumor necrosis factor-α (TNF-β) synthesis inhibitors. Synthesis involved utiliz...
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| Publié dans: | Bioorg Med Chem |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5187979/ https://ncbi.nlm.nih.gov/pubmed/21658960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.05.029 |
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