Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling

TET-family dioxygenases catalyze conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and oxidized methylcytosines in DNA. Here, we show that mouse embryonic stem cells (mESCs), either lacking Tet3 alone or with triple deficiency of Tet1/2/3, displayed impaired adoption of neural c...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Li, Xiang, Yue, Xiaojing, Pastor, William A., Lin, Lizhu, Georges, Romain, Chavez, Lukas, Evans, Sylvia M., Rao, Anjana
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187696/
https://ncbi.nlm.nih.gov/pubmed/27930333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617802113
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