Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

Active targeting of nanoparticles to tumours can be achieved by conjugation with specific antibodies. Specific active targeting of the HER2 receptor is demonstrated in vitro and in vivo with a subcutaneous MCF-7 breast cancer mouse model with trastuzumab-functionalized gold nanoparticles. The number...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Colombo, Miriam, Fiandra, Luisa, Alessio, Giulia, Mazzucchelli, Serena, Nebuloni, Manuela, De Palma, Clara, Kantner, Karsten, Pelaz, Beatriz, Rotem, Rany, Corsi, Fabio, Parak, Wolfgang J., Prosperi, Davide
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187442/
https://ncbi.nlm.nih.gov/pubmed/27991503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13818
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