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Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells
The development of autoimmune diabetes in the nonobese diabetic (NOD) mouse results from a breakdown in tolerance to pancreatic islet antigens. CD28-B7 and CD40 ligand–CD40 (CD40L-CD40) costimulatory pathways affect the development of disease and are promising therapeutic targets. Indeed, it was sho...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC518661/ https://ncbi.nlm.nih.gov/pubmed/15467837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420483 |
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