Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor

Nerve Growth Factor (NGF), the prototype of the neurotrophin family, is essential for maintenance and growth of different neuronal populations. The X-ray crystal structure of NGF has been known since the early '90s and shows a β-sandwich fold with extensive loops that are involved in the intera...

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Publicat a:Front Mol Biosci
Autors principals: Paoletti, Francesca, de Chiara, Cesira, Kelly, Geoff, Covaceuszach, Sonia, Malerba, Francesca, Yan, Robert, Lamba, Doriano, Cattaneo, Antonino, Pastore, Annalisa
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Molecular Biosciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5183593/
https://ncbi.nlm.nih.gov/pubmed/28083536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00083
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