Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor

Nerve Growth Factor (NGF), the prototype of the neurotrophin family, is essential for maintenance and growth of different neuronal populations. The X-ray crystal structure of NGF has been known since the early '90s and shows a β-sandwich fold with extensive loops that are involved in the intera...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Paoletti, Francesca, de Chiara, Cesira, Kelly, Geoff, Covaceuszach, Sonia, Malerba, Francesca, Yan, Robert, Lamba, Doriano, Cattaneo, Antonino, Pastore, Annalisa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5183593/
https://ncbi.nlm.nih.gov/pubmed/28083536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00083
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