Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor

Nerve Growth Factor (NGF), the prototype of the neurotrophin family, is essential for maintenance and growth of different neuronal populations. The X-ray crystal structure of NGF has been known since the early '90s and shows a β-sandwich fold with extensive loops that are involved in the intera...

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Bibliografiske detaljer
Udgivet i:Front Mol Biosci
Main Authors: Paoletti, Francesca, de Chiara, Cesira, Kelly, Geoff, Covaceuszach, Sonia, Malerba, Francesca, Yan, Robert, Lamba, Doriano, Cattaneo, Antonino, Pastore, Annalisa
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Molecular Biosciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5183593/
https://ncbi.nlm.nih.gov/pubmed/28083536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00083
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