SHANK3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons

Abnormal pain sensitivity is commonly associated with autism spectrum disorders (ASDs) and affects the life quality of ASD individual. SHANK3 deficiency was implicated in ASD and pain dysregulation. Here we report functional expression of SHANK3 in mouse dorsal root ganglion (DRG) sensory neurons an...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuron
Prif Awduron: Han, Qingjian, Kim, Yong Ho, Wang, Xiaoming, Liu, Di, Zhang, Zhi-Jun, Bey, Alexandra L., Lay, Mark, Chang, Wonseok, Berta, Temugin, Zhang, Yan, Jiang, Yong-Hui, Ji, Ru-Rong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182147/
https://ncbi.nlm.nih.gov/pubmed/27916453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.11.007
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