Proteome-wide profiling of clinical PARP inhibitors reveals compound-specific secondary targets

PARP inhibitors (PARPi) are a promising class of targeted cancer drugs, but their individual target profiles beyond the PARP family, which could result in differential clinical utility or toxicity, are unknown. Using an unbiased, mass spectrometry-based chemical proteomics approach, we generated a c...

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Publicado en:Cell Chem Biol
Main Authors: Knezevic, Claire E., Wright, Gabriela, Rix, Lily L. Remsing, Kim, Woosuk, Kuenzi, Brent M., Luo, Yunting, Watters, January M., Koomen, John M., Haura, Eric B., Monteiro, Alvaro N., Radu, Caius, Lawrence, Harshani R., Rix, Uwe
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182133/
https://ncbi.nlm.nih.gov/pubmed/27866910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.10.011
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