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Design and construction of generalizable RNA-protein hybrid controllers by level-matched genetic signal amplification

For synthetic biology applications, protein-based transcriptional genetic controllers are limited in terms of orthogonality, modularity, and portability. Although ribozyme-based switches can address these issues, their current two-stage architectures and limited dynamic range hinder their broader in...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Wang, Yen-Hsiang, McKeague, Maureen, Hsu, Tammy M., Smolke, Christina D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182110/
https://ncbi.nlm.nih.gov/pubmed/27840078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.10.008
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