Syrosingopine sensitizes cancer cells to killing by metformin

We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to syrosingopine’s known role as an inhibitor...

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Опубликовано в: :Sci Adv
Главные авторы: Benjamin, Don, Colombi, Marco, Hindupur, Sravanth K., Betz, Charles, Lane, Heidi A., El-Shemerly, Mahmoud Y. M., Lu, Min, Quagliata, Luca, Terracciano, Luigi, Moes, Suzette, Sharpe, Timothy, Wodnar-Filipowicz, Aleksandra, Moroni, Christoph, Hall, Michael N.
Формат: Artigo
Язык:Inglês
Опубликовано: American Association for the Advancement of Science 2016
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5182053/
https://ncbi.nlm.nih.gov/pubmed/28028542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601756
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