Cholesterol accumulation in CD11c+ immune cells is a causal and targetable factor in autoimmune disease

Liver X receptors (LXRs) are regulators of cholesterol metabolism that also modulate immune responses. Inactivation of LXR α and β in mice leads to autoimmunity; however, how the regulation of cholesterol metabolism contributes to autoimmunity is unclear. Here we found that cholesterol loading of CD...

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Detalhes bibliográficos
Publicado no:Immunity
Principais autores: Ito, Ayaka, Hong, Cynthia, Oka, Kazuhiro, Salazar, Jon V., Diehl, Cody, Witztum, Joseph L., Diaz, Mercedes, Castrillo, Antonio, Bensinger, Steven J., Chan, Lawrence, Tontonoz, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5181791/
https://ncbi.nlm.nih.gov/pubmed/28002731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.11.008
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