Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis

Mutation of highly conserved residues in transcription factors may affect protein-protein or protein-DNA interactions leading to gene network dysregulation and human disease. Human mutations in GATA4, a cardiogenic transcription factor, cause cardiac septal defects and cardiomyopathy. Here, iPS-deri...

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Publicado no:Cell
Main Authors: Ang, Yen-Sin, Rivas, Renee N., Ribeiro, Alexandre J. S., Srivas, Rohith, Rivera, Janell, Stone, Nicole R., Pratt, Karishma, Mohamed, Tamer M. A., Fu, Ji-Dong, Spencer, C. Ian, Tippens, Nathaniel D., Li, Molong, Narasimha, Anil, Radzinsky, Ethan, Moon-Grady, Anita, Yu, Haiyuan, Pruitt, Beth L., Snyder, Michael, Srivastava, Deepak
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5180611/
https://ncbi.nlm.nih.gov/pubmed/27984724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.11.033
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