Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

Single cardiomyocytes contain myofibrils that harbor the sarcomere-based contractile machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem cells (hPSC-CMs) have potential as an in vitro model of heart activity. However, their fetal-like misalignment of myofibrils lim...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ribeiro, Alexandre J. S., Ang, Yen-Sin, Fu, Ji-Dong, Rivas, Renee N., Mohamed, Tamer M. A., Higgs, Gadryn C., Srivastava, Deepak, Pruitt, Beth L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611612/
https://ncbi.nlm.nih.gov/pubmed/26417073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508073112
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