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Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

Matrix metalloproteinase-9 (MMP-9) is prominently overexpressed after myocardial infarction (MI). We tested the hypothesis that mice with targeted deletion of MMP9 have less left ventricular (LV) dilation after experimental MI than do sibling wild-type (WT) mice. Animals that survived ligation of th...

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Huvudupphovsmän: Ducharme, Anique, Frantz, Stefan, Aikawa, Masanori, Rabkin, Elena, Lindsey, Merry, Rohde, Luis E., Schoen, Frederick J., Kelly, Ralph A., Werb, Zena, Libby, Peter, Lee, Richard T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2000
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC517910/
https://ncbi.nlm.nih.gov/pubmed/10880048
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