Alix/AIP1 Antagonizes Epidermal Growth Factor Receptor Downregulation by the Cbl-SETA/CIN85 Complex

The assembly of the Cbl-SETA/CIN85-endophilin complex at the C terminus of the epidermal growth factor receptor (EGFR) following ligand activation mediates its internalization and ubiquitination. We found that the SETA/CIN85-interacting protein Alix/AIP1, which also binds endophilins, modulates this...

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Главные авторы: Schmidt, Mirko H. H., Hoeller, Daniela, Yu, Jiuhong, Furnari, Frank B., Cavenee, Webster K., Dikic, Ivan, Bögler, Oliver
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2004
Предметы:
Cell Growth and Development
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC517880/
https://ncbi.nlm.nih.gov/pubmed/15456872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.20.8981-8993.2004
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